Oxidative stress and inflammatory parameters in adult patients presenting with celiac disease

Authors

  • Alexandre Faraco Faculdade de Medicina – Universidade do Extremo Sul de Santa Catarina – Avenida Universitária 1105, Bairro Universitário - Criciúma - SC
  • Eliel Machado Rovaris Faculdade de Medicina – Universidade do Extremo Sul de Santa Catarina – Avenida Universitária 1105, Bairro Universitário - Criciúma - SC
  • Priscila Waleska Simões Faculdade de Medicina – Universidade do Extremo Sul de Santa Catarina – Avenida Universitária 1105, Bairro Universitário - Criciúma - SC
  • Monique Michels Programa de Pós Graduação em Ciências da Saúde – Laboratório de Fisiopatologia - Universidade do Extremo Sul de Santa Catarina – Avenida Universitária 1105, Bairro Universitário - Criciúma - SC http://orcid.org/0000-0001-8440-1976
  • Kristian Madeira Programa de Pós Graduação em Ciências da Saúde – Laboratório de Epidemiologia - Universidade do Extremo Sul de Santa Catarina – Avenida Universitária 1105, Bairro Universitário - Criciúma – SC
  • Samira Dal-Toé de Prá Programa de Pós Graduação em Ciências da Saúde – Laboratório de Bioenergética - Universidade do Extremo Sul de Santa Catarina – Avenida Universitária 1105, Bairro Universitário - Criciúma – SC
  • Andriele Vieira Programa de Pós Graduação em Ciências da Saúde – Laboratório de Fisiopatologia - Universidade do Extremo Sul de Santa Catarina – Avenida Universitária 1105, Bairro Universitário - Criciúma - SC
  • Henrique Burger Programa de Pós Graduação em Ciências da Saúde – Laboratório de Fisiopatologia - Universidade do Extremo Sul de Santa Catarina – Avenida Universitária 1105, Bairro Universitário - Criciúma - SC
  • Beatriz Sonai Programa de Pós Graduação em Ciências da Saúde – Laboratório de Fisiopatologia - Universidade do Extremo Sul de Santa Catarina – Avenida Universitária 1105, Bairro Universitário - Criciúma - SC
  • Emilio Streck Programa de Pós Graduação em Ciências da Saúde – Laboratório de Bioenergética - Universidade do Extremo Sul de Santa Catarina – Avenida Universitária 1105, Bairro Universitário - Criciúma – SC
  • Felipe Dal-Pizzol Programa de Pós Graduação em Ciências da Saúde – Laboratório de Fisiopatologia - Universidade do Extremo Sul de Santa Catarina – Avenida Universitária 1105, Bairro Universitário - Criciúma - SC

Keywords:

Celiac Disease, Gastroenterology, Inflammatory parameters, Oxidative stress, Nutrition, DOENÇA CELÍACA, ESTRESSE OXIDATIVO, GASTROENTEROLOGIA, NUTRIÇÃO, DOENÇAS AUTOIMUNES, DOENÇAS INFLAMATÓRIAS INTESTINAIS

Abstract

Celiac disease is a chronic small intestinal inflammatory condition caused by an inappropriate immune response to gluten of wheat, rye and barley, with a prevalence of about 1: 100 in the Caucasian population when occurs a inflammatory response and seems to involve high levels of interleukins. Objective: Determine the presence of oxidative stress and inflammation in the gut of patients with CD. Methods: Transversal study that included patients undergoing upper gastrointestinal (GI) endoscopy was performed. The study population consisted 24 cases and 26 controls. The duodenal levels of protein carbonyls, thiobarbituric acid reactive species (TBARS), as well as catalase (CAT), superoxide dismutase (SOD) activities were measured. Gut levels of interleukin (IL) 6, 10 and 8 were also determined. The Marsh classification was recorded and used as a parameter of disease severity. Results: Both IL-6 and IL-10, but not IL8, were increased in CD patients when compared to healthy individuals. Oxidative damage parameters were increased while antioxidant defenses were decreased in our sample. Both IL6 levels and SOD activity were related to Marsh score. Conclusions: Different markers of inflammation and oxidative stress are altered in the gut of CD patients, and some of them are related to disease severity.

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Published

2017-07-30

How to Cite

Faraco, A., Rovaris, E. M., Simões, P. W., Michels, M., Madeira, K., de Prá, S. D.-T., … Dal-Pizzol, F. (2017). Oxidative stress and inflammatory parameters in adult patients presenting with celiac disease. Revista Da Associação Brasileira De Nutrição - RASBRAN, 8(1), 64–69. Retrieved from https://rasbran.emnuvens.com.br/rasbran/article/view/428

Issue

Vol. 8 No. 1 (2017)

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Artigos Originais

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