Marcadores inflamatórios na avaliação nutricional: relação com parâmetros antropométricos, composição corporal e níveis de atividade física.
Keywords:
Doenças Cardiovasculares. Inflamação. Composição Corporal. Estado Nutricional. Atividade Física.Abstract
Objetivo: realizar um estudo de revisão sistemática referente ao uso dos marcadores inflamatórios como fator de risco de doença cardiovascular e sua relação com parâmetros antropométricos, bioquímicos, composição corporal e a influência do nível de atividade física. Métodos: Foi realizada uma revisão sistemática de literatura nas bases de dados eletrônicas: PUBMED, SciELO e Conchrane Collection. Utilizaram-se os termos associados “inflammation, cardiovascular diseases” e “nutritional status”, “inflammation, cardiovascular diseases” e “body composition” e “inflammation, cardiovascular diseases” e “physical activity”. Resultados: Encontraram-se 866 artigos entre os anos de 1998 e 2013, sendo 332 (38,3%) publicados entre os anos de 2009 e 2013. A associação entre os termos indexados que mais selecionou artigos originais foi “cardiovascular diseases, inflammation and physical activity”, com 526 artigos (60,74%). A obesidade foi o fator mais relacionado com os marcadores, e a prática de atividade física a principal medida não farmacológica para o controle do sobrepeso e processo de inflamação. Conclusão: As pesquisas avaliaram os marcadores inflamatórios nas doenças cardiovasculares relacionados com avaliação da composição corporal, do estado nutricional e da influência da atividade física. A atividade física e a dieta balanceada foram as medidas necessárias no controle da incidência ou prevalência dos marcadores inflamatórios. Estudos com delineamento longitudinal e de intervenção são necessários para avaliar precisamente como a composição corporal, o estado nutricional e a atividade física podem interferir na manifestação dos marcadores inflamatórios.
Objective: To conduct a systematic review regarding the use of inflammatory markers as a risk factor of cardiovascular disease and its connection with anthropometric, biochemical parameters, body composition and the influence of physical activity. Methods: A systematic literature review was conducted in the electronic databases PUBMED, SciELO e Conchrane Collection. The associated terms “inflammation, cardiovascular diseases” and “nutritional status”, “inflammation, cardiovascular disease” and “body composition” and “inflammation, cardiovascular diseases” and “physical activity were used. Results: 866 articles between the years 1998-2013, 332 (38.3%) having been published between the years 2009-2013, were found. The association that selected more original items among the indexed terms was "cardiovascular diseases, inflammation and physical activity", with 526 articles (60.74%). Obesity was the factor the most associated with inflammatory markers, and physical activity was the main nonpharmacological measure used against overweight and inflammation process. Conclusion: The research evaluated inflammatory markers in cardiovascular diseases related to the assessment of body composition, nutritional status and the influence of physical activity. Physical activity and a balanced diet are the measures necessary to control the incidence or prevalence of inflammatory markers. Intervention longitudinal studies are needed to assess precisely how body composition, nutritional status and physical activity can interfere in the manifestation of inflammatory markers.
Downloads
References
- Geraldo JM, Alfenas RCG. Papel da Dieta na Prevenção e no Controle da Inflamação Crônica – Evidências Atuais. Arq. Bras. Endocrinol. Metab 2008;52(6);951-967.
- Hopps E, Caimi G. Exercise in obesity management. J Sports Med Phys Fitness 2011;51(2):275-82.
- World Health Organization. Diet, nutrition and the prevention of chronic diseases: Report of a Joint WHO Expert Consultation, Geneva, 2004, WHO technical Report; 2004 (series, 916).
- Gottlieb MGV, Bonardi G, Moriguchi EH. Fisiopatologia e aspectos inflamatórios da aterosclerose. Sci Med (Porto Alegre) 2005;15(3):203-207.
- Teixeira-Lemos E et al. Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties. Cardiovasc Diabetol 2011;28:10-12.
- Duarte ER, Pellanda LC, Portal VL. Perfil Inflamatório, Metabólico e Lipídico na Síndrome Isquêmica Aguda: Relação com Eventos Intra e Pós-Hospitalares. Arq. Bras. Cardiol. 2005; 84 (2): 123-129.
- Tsarouhas k, Tsitsimpikou C, Haliassos A, Georgoulias P, Koutsioras I, Kouretas D, Kogias J, Liosis I, Rentoukas E, Kyriakides Z. Study of insulin resistance, TNF-α, total antioxidant capacity and lipid profile in patients with chronic heart failure under exercise. In Vivo 2011; 25 (6): 1031-7.
- Wu CK, Yang CY, Lin JW, Hsieh HJ, Chiu FC, Chen JJ, Lee JK, Huang SW, Li HY, Chiang FT, ChenJJ, Tsai CT. The relationship among central obesity, systemic inflammation, and left ventricular diastolic dysfunction as determined by structural equation modeling. Obesity (Silver Spring) 2012;20(4):730-7.
- Volp ACP, Alfenas RCG, Costa NMB, Minim VPR, Stringueta PC, Bressan J.Capacidade dos Biomarcadores Inflamatórios em Predizer a Síndrome Metabólica. Arq Bras Endrocrinol Metab 2008; 52 (3): 537-539.
- Poledne R, Lorenzová A, Stávek P, Valenta Z, Hubáček J, Suchánek P, Piťha J. Proinflammatory status, genetics and atherosclerosis. Physiol Res 2009; 58 (2) (Suppl 2):111-8.
- Ahmadi N. Effects of intense exercise and moderate caloric restriction on cardiovascular risk factors and inflammation. Am J Med 2011; 24 (10): 978-82.
– Yashamita AS, Lira FS, Rosa JC, Paulino EC, Brum PC, Carlos Eduardo Negrão et al. Depot-especific modulation of adipokine level in rat adipose tissue by diet-induced obesity. The effect of aerobic training and energy restriction. Cytokine 2010; 52: 168-174.
- Batista Jr ML, Rosa JC, Lopes, RD, Lira FS, Martins Jr. E, Yamashita AS et al. Exercise training changes IL-10/TNF-α ratio in the skeletal muscle of post-MI rats. Cytokine 2010; 49: 102-108.
– Fernandes JL, Serrano Jr CV, Toledo F, Hunziker, MF, Zamperini A, Teo FH, Oliveira RT, et al. Acute and effects of exercise on inflatory markers and B-type natriuretc peptic in patients with coronary artery disease. Clin Res Cardiol 2011; 100: 77-84.
- Petersen AMW, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol 2005; 98: 1154-1162.
- Williams DP, Teixeira PJ, Going SB. Exercise. In: Hymsfield et al. Body Human Composution. 2ª Ed. Guanabara Kogan; 2005. p. 313-330.
- Allison MA, Nicole E. Jensky NE, Marshall SJ, Bertoni AG, Cushman M Sedentary behavior and adiposity-associated inflammation: the Multi-Ethnic Study of Atherosclerosis. Am J Prev Med 2012; 42(1): 8-13.
- Puglizi MJ, Fernandez ML. Modulation of C-Reactive Protein, Tumor Necrosis Factor-a, and Adiponectin by Diet, Exercise, and Weight Loss. J. Nutr 2008;138: 2293–2296.
- Matos MF, Dayse M. Lourenço DM, Orikaza CM, Bajerl JAH, Noguti MAE, Morelli VM. The role of IL-6, IL-8 and MCP-1 and their promoter polymorphisms IL-6 -174GC, IL-8 -251AT and MCP-1 -2518AG in the risk of venous thromboembolism: a case-control study. Thromb Res 2011; 128(3):216-20.
- Kop WJ, Gottdiener JS, Tangen CM, Fried LP, McBurnie MA, Walston J et al. Inflammation and coagulation factors in persons > 65 years of age with symptoms of depression but without evidence of myocardial ischemia. Am J Cardiol 2002;15 (89) (4): 419-24.
- González-Juanatey JR, Lago Paz FL, Eiras S, Teijeira-Fernández E. Adipocitocinas como nuevos marcadores de la enfermedad cardiovascular. Perspectivas fisiopatológicas y clínicas. Rev Esp Cardiol 2009 ;62 (Suppl 2): 9-16.
- Siervo M, Ruggiero D, Sorice R, Nutile T, Aversano M, Iafusco M, et al. Body mass index is directly associated with biomarkers of angiogenesis and inflammation in children and adolescents. Nutrition 2012; 28 (3): 262-6.
- Falutz J. HIV infection, body composition changes and related metabolic complications: contributing factors and evolving management strategies. Curr Opin Clin Nutr Metab Care 2011; 14 (3): 255-60.
- Di Renzo L, Noce A, De Angelis S, Miani N, Di Daniele N, Tozzo C, De Lorenzo A. Anti-inflammatory effects of combined treatment with acetyl salicylic acid and atorvastatin in haemodialysis patients affected by Normal Weight Obese syndrome. Pharmacol Res 2008; 57 (2): 93-9.
- Tokgözoğlu L. Atherosclerosis and the role of inflammation. Turk Kardiyol Dern Ars 2009; 7 (Suppl 4):1-6.
- Dod HS, Bhardwaj R,Sajja V, Weidner G, Hobbs GR, Konat GW et al. Effect of intensive lifestyle changes on endothelial function and on inflammatory markers of atherosclerosis. Am J Cardiol 2010; 105(3): 362-7.
- Santos MG, Pegoraro M, Sandrini F, Macucol EC. Fatores de Risco no Desenvolvimento da Aterosclerose na Infância e Adolescência. Arq Bras Cardiol 2008; 90(4):301-308.
- Nunes APOB, Vinagre CGCM, Maranhão RC. Exercício e metabolismo de lípides plsmáticos. In: Negão CE, Barreto ACP. Cardiologia do exercício: do cardiopata ao atleta. 2 edição, Manole, Barueri-SP; 2006. p. 173-184.
- Kinlay S, Selwyn AP. Effects of statins on inflammation in patients with acute and chronic coronary syndromes. Am J Cardiol 2003; 91:9B–13B.
- Kasapis C, Thompson PD. The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review. J Am Coll Cardiol 2005;17(45)(10):1563-9.
- Kelly AS, Rachel J. Wetzsteon RJ, Kaiser DR, Steinberger J, Bank AJ,Dengel DR. Inflammation, insulin, and endothelial function in overweight children and adolescents: the role of exercise. The Journal of Pediatrics 2004;5:731-737.
- DeVan AE, Umpierre D, Harrison ML , Lin HF , Tarumi T , Renzi CP , Dhindsa M , Hunter SD , Tanaka H. Endothelial ischemia-reperfusion injury in humans: association with age and habitual exercise. Am J Physiol Heart Circ Physiol 2011;300(3):H813-9.
– Onat A. Metabolic syndrome: nature, therapeutic solutions and options. Expert Opin Pharmacother 2011;12(12):1887-1900.
- Tamakoshi A, Suzuki K, Lin Y, Ito Y, Yagyu K, Kikuchi SWatanabe Y et al. Relationship of sFas with metabolic risk factors and their clusters. Eur J Clin Invest 2010; 40 (6): 527-33.
- De León AC, Rodríguez Pérez MC, González DA, Díaz BB, Coello,1 Ana González SD, Hernández AG, Aguirre-Jaime A et al. Hemodynamics and metabolism at low versus moderate altitudes. High Alt Med Biol. Summer 2011;12(2):179-86.
- Libby P. Inflammation and cardiovascular disease mechanisms. Am J Clin Nutr 2006; 83 (2): 456S-460S.
- Guebre-Egziabher F, Kalbacher E, Fouque D. Insulin resistance and inflammation in chronic kidney diseases. Nephrol Ther 2009;5:(Suppl 5):S346-52.
- Paoletti R, Bolego C, Poli A, Cignarella A. Metabolic syndrome, inflammation and atherosclerosis. Vasc Health Risk Manag 2006; 2 (2): 145-52.
- Wang H, Steffen LM, Vessby B, Basu S, Steinberger J, Moran A, Jacobs JDR, Hong CP, Sinaiko AR. Obesity Modifies the Relations Between Serum Markers of Dairy Fats and Inflammation and Oxidative Stress Among Adolescents. Obesity 2011; (19): 2404–2410.
- Sardinha LB, Teixeira P. Measuring adiposity and fat distribuition in relation to health. In In: Hymsfield et al. Body Human Composution. 2ª Ed. Hardcover; 2005. p.177-201.
- Carvalho GQ, Pereira PF, Serrano HMS, Franceschini SCC, Paula SO et al. Peripheral expression of inflammatory markers in overweight female adolescents and eutrophic female adolescents with a high percentage of body fat. Appl. Physiol. Nutr. Metab 2010;35:464–470.
- Santos JCM, Rocha SM, Araújo SM. Determinantes Prognósticos em Pacientes com Síndrome Coronariana Aguda sem Elevação do Segmento ST. Arq. Bras. Cardiol. 2013;100(5):412-421.
- Martinez-Gomez D, Gomez-Martineza S, Ruizb JR, Diaza LE, Ortegac FB, Widhalme K, Cuenca-Garciad M, Manios Y et al. Objectively-measured and self-reported physical activity and fitness in relation to inflammatory markers in European adolescents: The HELENA Study. Atherosclerosis 2012;221:260– 267.
- Dulloo AG, Montani JP. Body composition, inflammation and thermogenesis in pathways to obesity and the metabolic syndrome: an overview. Obes Rev 2012; 13 (Suppl) p. 2:1-5.
- Alves ES, Lemos VA, Silva FR, Lira FS, Santos RVT, Rosa JP. Low-Grade Inflammation and Spinal Cord Injury: Exercise as Therapy? Mediators of inflammation 2013; 2013: 1-7.
- Garanty-Bogacka B, Syrenicz1 M, Goral J, Krupa B, Syrenicz J, Walczak M, Syrenicz A. Changes in inflammatory biomarkers after successful lifestyleintervention in obese children. Endokrynol Pol 2011:62(6) ):499-505.
- Faber DR, Van der Graaf Y, Westerink J, Visseren FLJ. Increased visceral adipose tissue mass is associated with increased C-reactive protein in patients with manifest vascular diseases. Atherosclerosis 2010; 212(1):2 74-80.
- Pate R, Pratt M, Blair SN, Haskell WL, Macera CA, Bouchard C, Buchner D et al. Physical activity and public health: a recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA 1995; 273 (5): 402-7.
- World Health Organization. Global Recommendations on Physical Activity for Health. In: Organization WH, editor. Geneva: WHO Press; 2010.
– American College of Sports Medicine (ACSM). Diretrizes do ACSM para os testes de esforço e sua prescrição. 6ª ed. Rio de Janeiro: Guanabara Koogan 2006.
- Pedersen BK, Steensberg A, Fischer C, Keller C Keller P, Plomgaard P, Febbraio M, Saltin B. Searching for the exercise factor: is IL-6 a candidate. J Muscle Res Cell Motil 2003; 24: 113-119.
- Hopps E, Caimi G. Exercise in obesity management. J Sports Med Phys Fitness 2011;51(2):275-82.
- Rosseti MB, Brito RR, Norton RC. Prevenção primária de doenças cardiovasculares na obesidade infantojuvenil: efeito anti-inflamatório do exercício físico. Rev Bras Med Esporte 2009;15(6):472-475.
- Armstrong N. Aerobic fitness of children and adolescents. J Pediatr (Rio J) 2006;2:406-8.
- Whayne Jr TF, Maulik N. Nutrition and the healthy heart with an exercise boost. Can J Physiol Pharmacol 2012;90(8):967-76.
- Witham MD, Linda J. Crighton LJ, Gillespie ND, Struthers AD, McMurdo MET. The effects of vitamin D supplementation on physical function and quality of life in older patients with heart failure: a randomized controlled trial. Circ Heart Fail 2010; 3 (2):195-201.
- Garelnabi M, Veledar E, White-Welkley J, Santanam N, Abramson J, Weintraub W, Parthasarathy S. Vitamin E differentially affects short term exercise induced changes in oxidative stress, lipids, and inflammatory markers. Nutr Metab Cardiovasc Dis 2012; 22 (10): 907-13.
- Panagiotakos DB, Dimakopoulou K, Katsouyanni K, Bellander T, Grau M, Koenig W, Lanki T et al. Mediterranean diet and inflammatory response in myocardial infarction survivors. Int J Epidemiol 2009;38(3):856-66.
– Lucas L, Russel A, Keast R. Molecular Mechanisms of Inflammation. Anti-Inflammatory Benefits of Virgin Olive Oil and the Phenolic Compound Oleocanthal. Current Pharmaceutical Design 2011; 17 (8): 754-768.
- Chacko SA, Song Y, Nathan L, Tinker L, Boer IH, Tylavsky F et al. Relations of dietary magnesium intake to biomarkers of inflammationand endothelial dysfunction in an ethnically diverse cohort of postmenopausal women. Diabetes Care 2010; 33 (2): 304-10.
- Di Giuseppe R, Di Castelnuovo ACentritto F, Zito F, Curtis A, Costanzo S et al. Regular consumption of dark chocolate is associated with low serum concentrations of C-reactive protein in a healthy Italian population. J Nutr 2008; 138 (10): 1939-45.
- Trombetta IC, Batalha LT, Halpern A. Exercício e Obesidade. In: Negão CE, Barreto ACP. Cardiologia do exercício: do cardiopata ao atleta. 2 edição, Manole, Barueri-SP; 2006. p. 154-172.
- Platat C, Wagner A, Klumpp T, Schweitzer B, Simon C. Relationships of physical activity with metabolic syndrome features and low-grade inflammation in adolescents. Diabetologia 2006;49(9):2078-85.
- Martinez-Gomez D, Eisenmann JC, Wärnberg J, Gomez-Martinez S, Veses A, Veiga OL, Marcos A. Associations of physical activity, cardiorespiratory fitness and fatness with low-grade inflammation in adolescents: the AFINOS Study. Int J Obes (Lond) 2010; 34(10): 1501-7.
- Karch I Olszowska M, Tomkiewicz Pająk L, Drapisz S, Łuszczak J, Podolec P. The effect of physical activity on serum levels of selected biomarkers of atherosclerosis. Kardiol Pol 2013;71(1):55-60.
- Buchan DS, Ollis S, Young JD, Thomas NE, Cooper SM, Tong TK et al. The Effects of Time and Intensity of Exercise on Novel and Established Markers of CVD in Adolescent Youth. Am J Hum Biol 2011; 23: 517-526.
- Byrkjeland R, Nilsson BB, Westheim AS, Arnesen H, Seljeflot I. Inflammatory markers as related to disease severity in patients with chronic heart failure: limited effects of exercise training. Scand J Clin Lab Invest 2011; 71 (7): 598-605.
- Ahmadi N. Effects of intense exercise and moderate caloric restriction on cardiovascular risk factors and inflammation. Am J Med 2011; 24 (10): 978-82.
- Lavoie ME, Rabasa-Lhoret R, Doucet E, Mignault D, Messier L, Bastard JP, Faraj M. Association between physical activity energy expenditure and inflammatory markers in sedentary overweight and obese women. Int J Obes (Lond) 2010; 34 (9): 1387-95.
- Lin YC, Chen PC, Kuo HK, Lin LY, Lin JW, Hwang JJ. Effects of obesity, physical activity, and cardiorespiratory fitness on blood pressure, inflammation, and insulin resistance in the National Health and Nutrition Survey 1999-2002. Nutr Metab Cardiovasc Dis 2010;20 (10): 713-9.
- Autenrieth C, Schneider A, Döring A, Meisinger C, Herder C, Koenig W, Huber G, Thorand B. Association between different domains of physical activity and markers of inflammation. Med Sci Sports Exerc 2009;41(9):1706-13.
- Hamer M, Stamatakis E. Physical activity and risk of cardiovascular disease events: inflammatory and metabolic mechanisms. Med Sci Sports Exerc 2009;41(6):1206-11.
- Majka DS, Chang RW, Vu TT, Palmas W, Geffken DF, Ouyang P, Ni H. Physical activity and high-sensitivity C-reactive protein: the multi-ethnic study of atherosclerosis. Am J Prev Med 2009; 36 (1): 56-62.
- Wannamethee SG, Shaper AG, Whincup PH, Lennon L, Sattar N. Adiposity, adipokines, and risk of incident stroke in older men. Stroke 2013; 44 (1): 3-8.
Downloads
Published
How to Cite
Issue
Section
License
A Revista se reserva no direito de efetuar, se necessário, alterações de ordem normativa, ortográfica e gramatical, com vistas a manter o padrão culto da língua, respeitando, porém, o estilo dos autores.
Ao encaminhar os originais, os autores cedem os direitos de primeira publicação para a Revista da Associação Brasileira de Nutrição e aceitam que seu trabalho seja publicado de acordo com nossa Declaração de Direito Autoral.
Os documentos publicados serão atribuídos a licença 
Este trabalho está licenciado com uma Licença Creative Commons - Atribuição 4.0 Internacional.
